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Bile Acid Reviews

Clinique de nutrition Physiologique acides biliaires

Why measure your bile acids?

Clinique de Nutrition Physiologique INFL

Do you suffer from any of these conditions  ?


  • chronic pain and / or discomfort centered on the stomach area with a feeling of heaviness, "overflow" or bloating accompanied by belching (burping).

  • chronic transit disorders ( diarrhea or constipation ) refractory to all treatments.

  • gallstones

  • chronic inflammatory bowel disease

  • intolerance to any drug treatment

  • chronic hypo or hypercholesterolemia

  • vitamin A or E or D or K deficiency resistant to any form of supplementation

  • unexplained increase in your GT gamma

  • polyarticular pain

  • retinal disease

  • family history of Alzheimer's disease

  • recurrent herpes

  • susceptibility to influenza virus

  • cholestasis with its intense pruritus (itching sensation) that appeared during your 2nd or 3rd trimester of pregnancy.

> In this case the problem may be with your bile acids and there are solutions to fix it.

What do we dose?

Primary bile acids and conjugated bile acids


AT THE LIVER LEVEL, primary acids are made from cholesterol and then stored in the gallbladder to be excreted in the intestine at the start of meals to allow digestion and absorption of fat soluble nutrients.

They are then reabsorbed at the level of the terminal ileum to return to the liver via the portal vein.

In the liver, primary bile acids are transformed into secondary bile acids, thanks to two amino acids, glycine and taurine, in order to make them less toxic to the liver.

The conjugated bile acids will be stored in the gallbladder and excreted in the intestine along with the primary bile acids.

Secondary bile acids


AT THE INTESTINAL LEVEL, a small part of the primary bile acids do not return to the liver and are transformed into secondary bile acids thanks to enzymes produced by certain bacteria in the intestinal microbiota.

What are the roles of bile acids?

Bile acids have receptors throughout the body and more particularly: intestines, kidneys, lungs, brain, bones.

Their roles, often underestimated, are therefore numerous:

1. Ensure the digestion and assimilation of fat-soluble nutrients:

These are fatty acids, vitamins A, E, D, K, carotenoids and phytosterols.

Poor digestion and assimilation of fat-soluble nutrients can lead to a deficit with repercussions on the state of health.

For example a vitamin D deficiency will lead to significant cardiovascular risks, risks of colorectal cancer, predisposition to viral and bacterial infections.

2.Regulate the amount of water in the digestive tract:

If you are chronically constipated or on the contrary if you have permanent diarrhea the problem may be with your bile acids because they regulate the absorption of sodium and liquid secretions in the colon.

3. Ensure a good seal of your intestinal barrier:

By regulating the proliferation and death of intestinal cells, bile acids prevent intestinal hyperpermeability responsible for digestive disorders and distant disorders such as migraines, joint pain ...

4. Provide hepatic detoxification:

Bile acids allow the elimination of hepatotoxic compounds and therefore make it possible to avoid the clinical signs of hepatic fatigue (nausea, headaches, etc.) as well as pathologies that can affect the liver (inflammation, cirrhosis, cancer).

5.Regulate the metabolism of carbohydrates, lipids and cholesterol:

Bile acids therefore make it possible to prevent metabolic disorders that can lead to diabetes and / or obesity.

6. Modulate immunity: better antibacterial and antiviral defense:

Bile acids allow us to have an adapted response to a virus or bacterial infection by intervention directly on the immune system but also indirectly by action on the intestinal microbiota.


7. Prevention of osteoporosis:

As we know today, bile acids are able to attach themselves to the bones.

An imbalance in their synthesis will be a factor favoring osteoporosis and fractures.

8. Regulation of serotonin:

Serotonin is the hormone of happiness. Secreted for the most part at the intestinal level, its level is regulated by secondary bile acids.

Any imbalance in the synthesis of secondary bile acids can lead to mood disturbances.

9. Particular role of ATUDC conjugated bile acid:

This bile acid would have a protective effect against neurodegenerative diseases (Alzheimer's) but also against retinal degeneration.

It is also able to inhibit the influenza A virus and modulate that of herpes.

10. Bile acids and pregnancy:

An imbalance of bile acids can be the cause of disturbed bile excretion during pregnancy.

It is also the bile acids of the newborn that allow the correct maturation of his intestinal microbiota.

What treatments to offer

Whatever your state of health, it is important to balance the synthesis of bile acids.

Your analysis results will allow us to determine precisely which bile acids (primary, secondary or conjugated) are in excess and / or in deficit, to offer you an individual treatment and to follow the progress of this treatment thanks to a control of the balance sheet.

Acides Biliaires

Bile acids that get better

Clinique de nutrition Physiologique acid
Vitamines liposolubles

Fat soluble vitamins

Fat soluble vitamins are vitamins that need to be emulsified by bile acids to be assimilated.

A lack of bile acids can lead to poor assimilation of fat-soluble vitamins consumed with the appearance of corresponding clinical signs.

Fat soluble vitamins are:


Vitamin A: is found in two forms: retinol (animal origin) and carotenes (plant origin in the form of a precursor of vitamin A called provitamin A).

Vitamin A plays an important role in vision, immune system function, growth, differentiation and cell growth.

Vit A deficiency can lead to skin disorders, ossification, growth, chronic infections (Excessive and prolonged alcohol consumption can lead to vitamin A deficiency).

Vitamin D: Calciferol

It increases the digestive absorption of calcium and its mobilization from the bone and decreases renal excretion.

Role in the immune system by acting on the differentiation and maturation of mononuclear cells.

A deficiency leads to disorders in: phosphocalcic homeostasis, muscle function, respiratory function, stimulation of innate immunity, inhibits acquired immunity, anti-microbial activity, cardiovascular disease, insulin resistance, cancers, hepatic function.

Water-soluble vitamins:

Vitamin B9: folic acid.

Intervenes in cell growth (fetal development) and in the prevention of cardiovascular pathologies. The needs are increased when taking oral contraceptives, smoking, excessive alcohol consumption. Deficiencies are present in pregnant women, the elderly, gastrectomies.

Deficits can cause nonspecific neurological disorders, digestive disorders, fetal malformations.

Vitamin B12: cobalamin

Plays a role in the prevention of cardiovascular disease and in cell division.

Deficiencies are possible by veganism (plants do not contain an active form of vitamin B12), gastric problem (Helicobacter pylori), digestive disorders and can cause anemia, sensitive neuropathies, glossitis.

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Bilan des acides biliaires
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