Civilization Disease Prevention Assessment
Are you in pain? or do you have in your family cases of
Allergies, recurrent infections
Ocular (macular degeneration, cataract, dry eye)
Cerebral (Alzheimer's, stroke)
Vascular (myocardial infarction, Raynaud's syndrome, venous stasis, phlebitis, arteritis)
Metabolic (overweight, obesity, non-insulin-dependent diabetes).
> You then risk developing a disease of civilization
Diseases of civilization are defined as diseases related to the way people live their lives. These diseases are the consequences of the degradation of our environment or of our lifestyles.
The cells that make up our human body are constantly attacked by free radicals and when our body no longer has the possibility of defending itself then the pathology begins.
These attacks can come from outside (smoking, excessive ingestion of alcohol, ingestion of oxidized oils (frying), heat, UV rays from the sun, pesticides and various pollutants) but also attacks produced by our own cells ( cellular respiration, immune reactions, inflammation, liver detoxification).
Free radicals are very reactive (or unstable) that is to say that they will (if they are not neutralized) lead to harmful consequences for health:
In the cell (Denaturation of proteins, oxidation of membrane and circulating lipids, and alteration of DNA (Poor enzymatic and hormonal functioning, cancer).
In the extracellular matrix and in particular the connective tissue (attack on ligaments, cartilage, arteries).
Oxidative or oxidative stress is an attack on cells by an excess of free radicals. It sets in when there is an overproduction of free radicals and / or an insufficient neutralization.
To fight against free radicals, the body produces its own defenses or draws them from our food: these are anti-oxidants .
Prolonged oxidative stress is a condition which does not yet constitute a proven disease but reflects a break between a state of health and an intermediate state (premature aging, pre-illness).
In the event of illness, the management of oxidative stress will allow a faster return to recovery.
What are the markers of a disease of civilization?
Highly sensitive CRP : is the marker of invisible chronic inflammation (low grade) or significant localized inflammation (high grade). The production of excessive amounts of pro-inflammatory compounds promotes cancer development and / or progression by causing DNA damage, inhibiting the death of the infected cell, and stimulating cell migration and invasion.
Glutathione and Thioredoxin : help regulate antioxidant defenses. An excess indicates the existence of a center of production of free radicals or an excess of external contribution. An insufficiency may be due to a deficit of synthesis or to overconsumption by prolonged or significant anti-radical defense.
IGF1 is a protein related to growth hormone. It allows the development of atherosclerosis to be evaluated and its signaling has been found in colon cancer, in thyroid cancer and in breast cancer.
IGFPB3 is the main transporter of IGF1. Its rate can be modified during hyperthyroidism, chronic renal failure, diabetes, breast, ovarian and prostate cancer.
The Homa and Quicki indices are calculated from plasma values of insulinemia (hormone that regulates the amount of sugar in the blood) and glycemia (amount of sugar in the blood) measured in a fasting individual. These indices make it possible to evaluate insulin resistance for HOMA and sensitivity to this hormone for QUICKI and to determine possible risk factors for type 2 diabetes.
Zinc is a metal essential for the functioning of our cells. It is a cofactor of more than two hundred biochemical reactions involved in particular in cell division and antioxidant defenses. Zinc is essential for the functioning of the immune system and is involved in tissue renewal and healing. It is also involved in taste and olfactory functions but also in synaptic neurotransmission.
Selenium is a cofactor of antioxidant enzymes. Without it these enzymes are ineffective. It is also involved in the functioning of the thyroid.
ß carotene : A higher risk of cancer and cardiovascular disease in men with the lowest initial beta-carotene levels
Lycopene : Inhibition by lycopene metabolites of inflammation, hepatic and prostate carcinogenesis.
Lutein and Zeaxanthin : the eye is the organ that produces the most free radicals. For this it has two specific anti-oxidants: lutein and zeaxanthin. A deficit of one or both of these antioxidants are risk factors for AMD and / or dry eye.
Cryptoxanthin is a natural pigment that is found in particular in certain fruits such as tangerine, orange or papaya. Cryptoxanthin has a structure similar to beta-carotene. Like the latter, it is the precursor of vitamin A, a powerful fat-soluble antioxidant that protects cell membranes and lipoproteins.
Erythrocyte B9 : its deficit induces a risk of local hypermethylation of 8 genes involved in lung carcinogenesis.
B9 intake is inversely associated with breast cancer risk
B12 active : Mainly responsible for neurological or haematological disorders.
Vitamin D : a vitamin deficiency has been demonstrated as a risk factor for breast cancer, gastric and colorectal cancer.
On the other hand, an excess of this vitamin is associated with an increased risk of prostate K
Hepcidin : indirect marker of the mechanisms of carcinogenesis. The increase in hepcidin is one of the key mechanisms of carcinogenesis.
PAGE : erythrocyte fatty acids are all the fats that make up the wall of our cells. This membrane must be neither too rigid nor too flexible and contain a balance of pro-inflammatory fatty acid to defend itself and anti-inflammatory to be able to stop the inflammation in time.
An excess of saturated fatty acids increases oxidative stress.
The systemic ratio ω6 / ω3 is correlated with the risk of developing any cancer. The more this ratio is between 2 and 4, the lower the risk. It is the relationship between ω6 and ω3 which constitutes real useful data for primary, secondary and tertiary cancer prevention.
Trans-elaïdic acid which is the reflection of high temperature cooking (industrial or domestic) is associated with cardio-vascualar diseases and cancer risk factors (breast cancer: risk practically doubled compared to women who have the highest rate. lower)
Trans-palmitoleic fatty acid can decrease the risk of type 2 diabetes, associated with a significant decrease in CRPus, insulin resistance, triglycerides.
Rumenic acid allows the proper functioning of the immune system, anti-proliferative and slows the progression of atherothrombosis.
Lymphocyte typing and protein profile see immunity assessment .
Calprotectin, B2D, IgAs see digestive assessment